Is Sucrose Intolerance Hereditary?
Sucrose Intolerance caused by Congenital Sucrase-Isomaltase Deficiency (CSID) is a rare, inherited condition. When you have CSID, you are born with a hereditary disease. A “hereditary disease” means that the disease is caused by an inherited genetic mutation, which may affect multiple family members. CSID is generally inherited in an autosomal recessive pattern, explained by the Mayo Clinic to mean you inherit two mutated genes, one from each parent.
However, just because one of your parents carries the mutation, does not mean it will be passed down you and your siblings. On the other hand, one child may develop CSID, but a sibling may not. There is evidence that individuals with only one mutated gene associated with CSID may also experience symptoms of CSID.
According to statistics in the National Institutes of Health, U.S. Library of Medicine, this condition is estimated to affect 1 in 5,000 people of European descent, but it is much more prevalent in the native populations of Greenland, Alaska, and Canada, where as many as 1 in 20 people may be affected. Additionally, a review of studies conducted around the world for nearly 35,000 children found 9.0% of these gastrointestinal patients, who had a small intestinal assay for sucrase activity, were found to have CSID.
Sucrose Intolerance caused by CSID causes a reduction in the activity of the compound enzyme sucrase-isomaltase. Sucrase breaks down the sugar molecule sucrose, and isomaltase breaks down the bonds linking sugars found in starches. Without sucrase-isomaltase, your body is unable to break down sucrose, resulting in gastrointestinal symptoms. Symptoms of stomach pain, chronic diarrhea, gas, and bloating are common if you have CSID. For children with CSID, symptoms of failure to thrive (poor physical growth), symptoms that mimic chronic colic, and diaper rash also have been seen.
Although Sucrose Intolerance caused by CSID is hereditary, treatment options are available. Both diet therapy and medication may be needed to help resolve symptoms of this disease. Take the Sucrose Intolerance quiz and speak with your physician if you believe Sucrose Intolerance caused by CSID is causing your gastrointestinal symptoms.
Information contained on this site is not to be used as a substitute for talking to your doctor. You should always talk to your doctor about diagnosis and treatment information.
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